![]() ![]() Insertion on the transactivation and DNA-binding functions of the chimeric receptor. ![]() The corresponding domain from hRXR beta3, were used to investigate the consequences of the SLSR Chimeric receptors, in which the ligand-binding domain of hRXR alpha was substituted by Transcription polymerase chain reaction (RT-PCR) in all human tumor cell lines and mouse tissuesĮxamined. The isoform is generated by alternate use of a 3' splice acceptor site and is detectable by reverse Mammalian RXR - interactions during transcriptional activationĪn isoform of hRXR beta, termed hRXR beta3, contains an in-frame insertion of four amino acids (SLSR) in the ligand binding domain at codon 419. ![]()
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March 2023
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